Turning Up the Pressure on Vascular Disease

Author(s): Kenneth MaiesePages 291-293 (3) Abstract: Vascular cell injury, whether it occurs in the central nervous system or in other locations throughout the body, represents a significant factor for subsequent disability and death in individuals worldwide. In fact, coronary artery disease remains the leading cause of mortality and can be caused by vessel stenosis, atherosclerosis, embolic disease, or thrombosis. Loss of blood flow to critical areas in the vascular system leads to endothelial cell dysfunction and death. Treatments to avert...

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Platelets in the Alzheimer’s Disease Brain: do they Play a Role in Cerebral Amyloid Angiopathy?

Author(s): Kathrin M. Kniewallner, Daniela Ehrlich, Andreas Kiefer, Josef Marksteiner and Christian HumpelPages 4-14 (11) Abstract: Alzheimer’s disease (AD) is characterized by extracellular beta-amyloid plaques and intracellular tau tangles. AD-related pathology is often accompanied by vascular changes. The predominant vascular lesions in AD are cerebral amyloid angiopathy (CAA) and arteriosclerosis. Platelets circulate along the vessel wall responding immediately to vascular injury. The aim of the present study was to explore the presence...

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Low Baseline Urine Creatinine Excretion Rate Predicts Poor Outcomes among Critically Ill Acute Stroke Patients

Author(s): Chia-Yu Hsu, Yi-Ling Wu, Chun-Yu Cheng, Jiann-Der Lee, Ying-Chih Huang, Ming-Hsueh Lee, Chih-Ying Wu, Huan-Lin Hsu, Ya-Hui Lin, Yen-Chu Huang, Hsin-Ta Yang, Jen-Tsung Yang, Meng Lee and Bruce OvbiagelePages 47-52 (6) Abstract: Urinary creatinine excretion rate (CER) is an established marker of muscle mass. Low CER has been linked to poor coronary artery disease outcomes, but a link between CER and acute stroke prognosis has not been previously explored. We prospectively collected data from patients with acute stroke (ischemic or hemorrhagic)...

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MicroRNAs and Stem Cells to the Rescue

Author(s): Kenneth MaiesePages 211-213 (3) Affiliation: Laboratory of Cellular and Molecular Signaling Cancer Center, F 1220 New Jersey Health Sciences University 205 South Orange Avenue, Newark, NJ 07101, USA. Read Full-Text arti...

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Perfusion-diffusion Mismatch Predicts Early Neurological Deterioration in Anterior Circulation Infarction without Thrombolysis

Author(s): Chia-Yu Hsu, Chun-Yu Cheng, Yuan-Hsiung Tsai, Jiann-Der Lee, Jen-Tsung Yang, Hsu-Huei Weng, Leng-Chieh Lin, Ying-Chih Huang, Meng Lee, Ming-Hsueh Lee, Chih-Ying Wu, Ya-Hui Lin, Huan-Lin Hsu, Hsin-Ta Yang, Yi-Ting Pan and Yen-Chu HuangPages 277-282 (6) Abstract: Perfusion-diffusion mismatch in magnetic resonance imaging (MRI) represents the non-core hypoperfused area in acute ischemic stroke. The mismatch has been used to predict clinical response after thrombolysis in acute ischemic stroke, but its role for predicting early neurological...

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