Friday, 9 December 2016
Thursday, 1 December 2016
Thursday, 24 November 2016
Wednesday, 9 November 2016
Call For Paper
Bentham Science Publishers would like to invite you to submit your research paper for publishing in the Journal of
Current Neurovascular Research
Current Neurovascular Research
Thursday, 3 November 2016
Highlighted Article: Mean Platelet Volume During Ischemic Stroke is a Potential Pro-inflammatory Biomarker in the Acute Phase and During Neurorehabilitation Not Directly Linked to Clinical Outcome
Mean Platelet Volume During Ischemic Stroke is a Potential Pro-inflammatory Biomarker in the Acute Phase and During Neurorehabilitation Not Directly Linked to Clinical Outcome
Author(s):
Irene Ciancarelli, Daniela De Amicis, Caterina Di Massimo, Caterina Pistarini and Maria Giuliana Tozzi Ciancarelli Pages 177 - 183 ( 7 )
Abstract:
The prognostic role of increased mean platelet volume (MPV), as an indicator of platelet activation and large, more reactive platelets, in clinical and functional outcome of ischemic stroke is still conflicting. Studies are not currently available on the association between MPV and stroke recovery after neurorehabilitation. The relationship between MPV and clinical and functional outcome measures was assessed in twenty-four patients in the acute phase of first-ever ischemic stroke, and before and after 8-week intensive multifunctional neurorehabilitation. Neurorehabilitation was associated with improved scores of the National Institutes of Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the modified PULSES profile (mPULSES). When compared with apparently healthy subjects, higher MPV values were observed in stroke patients 24 hours after stroke and before neurorehabilitative treatment started not later than 14 days after stroke. Decreased MPV values were found after neurorehabilitation, even if the absolute values were still higher than those detected in control subjects. No correlation was observed between MPV values and scores of the NIHSS and mRS scales evaluated in stroke acute phase. No correlation was also observed before and after neurorehabilitative treatment between MPV and NIHSS, mRS and mPULSES scores. Our data provide evidence of the effectiveness of neurorehabilitation on modulating MPV values and support the hypothesis that high MPV could represent an expression of proinflammatory condition of the stroke patients, realistically pre-existent to acute ischemic event, than a marker of neurologic deficit and disability or of stroke recovery including motor performance and functional independence.
Keywords:
Mean Platelet Volume, ischemic stroke, neurologic deficit, disability, stroke recovery, neurorehabilitation.
Affiliation:
Department of Life, Health and Environmental Sciences, University of L’Aquila, Edificio Delta 6, Piazzale Salvatore Tommasi,1 - 67100 Coppito 67100, L'Aquila - Italy
For More Information Please Visit Our Website Current Neurovascular Research
Wednesday, 26 October 2016
Most Accessed Article: Assessment and Imaging of the Cerebrovascular Glycocalyx
Assessment and Imaging
of the Cerebrovascular Glycocalyx
Author(s):
Roel Hubert Louis Haeren, Steffi Elisabeth
Maria van de Ven, Marcus Anna Maria Jacobus van Zandvoort, Hans Vink, Jacobus
Johannes van Overbeeke, Govert Hoogland and Kim RijkersPages 249-260 (12)
Abstract:
The glycocalyx is a gel-like layer lining the luminal surface of the endothelium. The glycocalyx exerts an important barrier role because it prevents exposure of plasma components to the endothelial surface. Disruption of the glycocalyx by local inflammation or ischemia results in decreased glycocalyx thickness which is associated with a number of vascular diseases. The cerebrovascular glycocalyx has sparsely been studied, but is of great interest because of its potential role in cerebrovascular disease. In this review, we describe all existing techniques to visualize the glycocalyx and designate techniques that may be suitable for studying the cerebrovascular glycocalyx.
A total of seven imaging techniques are
discussed thoroughly, including transmission electron microscopy, intravital
microscopy, micro-particle image velocimetry, confocal laser scanning
microscopy, two-photon laser scanning microscopy, orthogonal polarization
spectral imaging and sidestream dark field/oblique imaging. Measurement of
serum concentrations of glycocalyx-specific constituents is another method for
glycocalyx analysis. Also, we have reviewed the methods of glycocalyx analysis
by using these imaging techniques.
So far, the cerebrovascular glycocalyx has
only been studied in vitro. However, other cerebral microcirculatory properties
have been studied in vivo. This suggests that the cerebrovascular glycocalyx
can be studied in vivo by using some of the described techniques, when specific
software is subjoined to the analysis.
In conclusion, we have summarized techniques
available for glycocalyx assessment, and explained the significance and
technical possibilities regarding cerebrovascular glycocalyx visualization.
Cerebrovascular glycocalyx assessment would add valuable information to our
understanding of the pathophysiology of cerebrovascular disease. Moreover, as a
part of the blood-brain barrier, more knowledge on the cerebrovascular
glycocalyx may lead to better understanding of neurodegenerative conditions
that are caused by a compromised blood-brain barrier including Alzheimer's
disease, vascular dementia, multiple sclerosis and epilepsy.
Keywords:
Glycocalyx, microscopy, review, technique,
cerebral, blood-brain barrier.
Affiliation:
Maastricht University Medical Center,
Department of Neurosurgery, PO box 5800, 6202 AZ Maastricht, The Netherlands.
For More Information Please Visit Our Website Current Neurovascular Research
